Through novel approaches we are applying photophysics in molecular spectroscopy and microscopy to the important and complex challenges to be found in biomolecules, skin, colloids, and nanoparticles. Our present emphasis is at the biomedical and nanometrology interface across a range of interconnected projects. Recent publications and areas of research reflect this focus and include:
Melanin and melanoma. Emphasis on structural determination and control for healthcare and new technology applications. See Metal ion influence on eumelanin fluorescence and structure. J-U Sutter and D J S Birch. Methods Appl. Fluoresc. 2, 024005, 2014.
Fibril formation in neurology. Methods of detection, formation and characterization of protein self-assemblies. See Tyrosine photophysics during the early stages of β-amyloid aggregation leading to Alzheimer’s. O J Rolinski, T Wellbrock, D J S Birch, V Vyshemirsky. J. Phys. Chem. Lett. 6, 3116-3120, 2015.
Super-resolution and single molecules. New techniques and applications of fluorescence detection and imaging below the diffraction limit. See Photometric three-dimensional super-resolution microscopy. C Franke, M Sauer and S van de Linde (Nature, in press).
Gold nanoprobes as cancer biomarkers. Photophysics and application in sensing and imaging. See G Wei, D Simionesie, J Sefcik, J U Sutter, Q Xue, J Yu, J Wang, D J S Birch and & Yu Chen, Optics Letts. 40, 5738-5741, 2015.
Gold clusters. Fundamental physics and application of sub-Bohr radii gold clusters as probes. See Locating the nucleation sites for protein encapsulated gold nanoclusters: A molecular dynamics and fluorescence study. B Russell, K Kubiak-Ossowska; P Mulheran, D J S Birch and Yu Chen. Phys. Chem. Chem. Phys. 17, 21935-21941, 2015.
Nanoparticle metrology. Dynamics of particle self-assembly and metrology in the 1-10 nm range. Nanoparticle metrology of silica colloids and super-resolution studies using the ADOTA fluorophore. H L Stewart, P Yip, M Rosenberg, T J Sørensen, Bo W. Laursen, A E Knight, and D J S Birch. Meas. Sci. Technol. 27, 045007, 2016.
Metabolic monitoring. In-vivo fluorescence sensing e.g. in-vivo glucose measurement for diabetes management using fluorescence lifetime. See Fluorescence intensity- and lifetime-based glucose sensing using glucose/galactose-binding protein. J C Pickup, F Khan, Z-L Zhi, J Coulter, D J S Birch. J. Diabetes Sci. and Technol. 7, 62–71, 2013