Recent Publications

Sudlow Site II of Human Serum Albumin remains functional after Gold Nanocluster Encapsulation: a Fluorescence-Based Drug Binding Study of L-Dopa. B A Russell, A Garton, A S Alshammaria, D J S Birch and Y Chen. Methods Appl. Fluoresc. 6, 035017, 2018.

A 192 x 128 Time Correlated Single Photon Counting Imager in 40nm CMOS Technology. R K Henderson, N Johnston, H Chen, D Day-Uei Li, G Hungerford, R Hirsch, D McLoskey, Philip Yip, and D J S Birch. RSSCIRC Proc. (In press).

Plasmon-Promoted Electrochemical Oxygen Evolution Catalysis from Gold Decorated MnO2 Nanosheets under Green Light. J Xu, P Gu, D J S Birch and Y Chen. Adv. Functional Mater. (In press).

HyphaTracker: An ImageJ toolbox for time-resolved analysis of spore germination in filamentous fungi. M Brunk, S Sputh, S Doose, S  van de Linde, U Terpitz.  Scientific Reports 8, Article Number: 605, 2018. DOI: 10.1038/s41598-017-19103-1

Formation of microcapsules by ultrasound stimulation for use in remote-controlled drug-eluting stents. W Yao, Y Bao, Y Chen. Medical Engineering and Physics, 56, 42-47, 2018. doi.org/10.1016/j.medengphy.2018.04.001.

Comparative analysis of the toxicity of gold nanoparticles in zebrafish Patibandla Srinath, Y Zhang, M A Tohari, P Gu, J Reilly, Yu Chen X Shu. J. App. Toxicology, 2018. doi.org/10.1002/jat.3628

Probing beta amyloid aggregation using fluorescence anisotropy: experiments and simulation.  M Onorio; T Wellbrock, O J Rolinski, K Kubiak-Ossowska, P A Mulheran. Phys. Chem. Chem. Phys. 20, 4216-4225, 2018.

12th FluoroFest International Workshop April 24–26, 2017. D J S BirchMethods Appl. Fluoresc. 6, 020201, 2018.     DOI:org/10.1088/2050-6120/aaa7bf

Detecting beta-amyloid aggregation from the time-resolved emission spectra. A Alghamdi, V Vyshemirsky, D J S Birch, O J Rolinski. Methods Appl. Fluoresc. 6, 024002, 2018. DOI:org/10.1088/2050-6120/aa9f95

NAD(P)H as a potential intrinsic probe for tumour margin estimation. H Stewart, T Hupp and D J S Birch. SPIE Proc. 10478, 2018. DOI: 10.1117/12.2287414

Tracking the formation of eumelanin from L-Dopa using coupled measurements. P Yip, J U Sutter. Methods Appl. Fluoresc. 6, Article Number:  027001, APR 2018.

Insulin aggregation tracked by its intrinsic TRES.L H C Chung, D J S Birch, V Vyshemirsky, M G Ryadnov and O J Rolinski. Appl. Phys. Letts.111, 2017. DOI.org/10.1063/1.5008477

Photometry unlocks 3D information from 2D localization microscopy data. C Franke, M Sauer, S van de Linde. Nature Meth. 14, 41-44, 2017.

A surface plasmon enhanced FLIM-FRET imaging approach based on Au nanoparticles.Y Zhang, J Yu, D J S Birch and Y Chen. Med. Dev. and Diag. Eng. 2(1), 78-82, 2017. DOI: 10.15761/MDDE.1000119

Finding the time for fluorescence. Its measurement and applications in life science. D J S Birch and D McLoskey. Readout: HORIBA Technical Reports, pp. 13-20, 2017

Outgoing Editor-in-Chief: exciting times at Measurement Science and Technology! D J S Birch. Meas. Sci. Technol. 28, Article Number:  010101, 2017. DOI: 10.1088/1361-6501/28/1/010101.

Lysozyme encapsulated gold naoclusters: effects of cluster synthesis on natural protein characteristics, B. A. Russell, B. Jachimska, P. Komorek, P.A. Mulheran and Y. Chen, Physical Chemistry Chemical Physics. 19, 7228-7235, 2017.

Building a quality home for fluorescence.D J S Birch, Yves Mely and O Wolfbeis. Methods Appl. Fluoresc. 4, Article Number: 040401, 2016. DOI: 10.1088/2050-6120/4/4/040401.

Hairpin DNA-functionalized gold nanorods for mRNA detection.W Guoke, Y Jun, W Jinliang, D J S Birch and Yu Chen. J. Biomed. Opt. 21, Article Number:  097001, 2016. DOI: 10.1117/1.JBO.21.9.097001.

Towards unsupervised fluorescence lifetime imaging using low dimensional variable projection. Y Zhang, A Cuyt, WS Lee, G Lo Bianco, G Wu, Y Chen, DDU Li. Opt. Express. 24, 26777-26791, 2016. DOI: 10.1364/OE.24.026777

Optimizing laguerre expansion based deconvolution methods for analysing bi-exponential fluorescence lifetime images. Y. Zhang, Y. Chen and D. Day-Uei Li, Opt. Express 24, 13894-13905, 2016.

GPU acceleration of time-domain fluorescence lifetime imaging, G. Wu, T. Nowotny, Y. Chen and D. Day-Uei Li, J. Biomed. Opt. 21(1), 017001 (2016). doi: 10.1117/1.JBO.21.1.017001.

Human serum albumin encapsulated gold nanoclusters: effects of cluster synthesis on natural protein characteristics, B. A .Russell,   B. Jachimska,   I. Kralka, P. A. Mulheran and   Y. Chen, J. Mater. Chem. B, 4, 6876-6882, 2016.

Probing the Sudlow Binding Site with Warfarin: How Does Gold Nanocluster Growth Alter Human Serum Albumin?  B Russell, K Kubiak-Ossowska; P Mulheran, D J S Birch and Yu Chen. Phys. Chem. Chem. Phys. 2016. DOI: 10.1039/c6cp03428d

Resolving environmental microheterogeneity and dielectric relaxation in fluorescence kinetics of protein.O J Rolinski, D McLaughlin, D J S Birch and V Vyshemirsk. Methods Appl. Fluoresc.4, 024001, 2016

Nanoparticle metrology of silica colloids and super-resolution studies using the ADOTA fluorophore. H L Stewart, P Yip, M Rosenberg, T J Sørensen, Bo W. Laursen, A E Knight, and D J S Birch.  Meas. Sci. Technol. 27, 045007, 2016

Revealing the photophysics of gold-nanobeacons via time-resolved fluorescence spectroscopy. G Wei, D Simionesie, J Sefcik, J U Sutter, Q Xue, J Yu, J Wang, D J S Birch and & Yu Chen, Optics Letts. 40, 5738-5741, 2015.

Tyrosine photophysics during the early stages of β-amyloid aggregation leading to Alzheimer’s. O J Rolinski, T Wellbrock, D J S Birch, V Vyshemirsky J. Phys. Chem. Lett. 6, 3116-3120, 2015.

Locating the nucleation sites for protein encapsulated gold nanoclusters: A molecular dynamics and fluorescence study. B Russell, K Kubiak-Ossowska; P Mulheran, D J S Birch and Yu Chen. Phys. Chem. Chem. Phys. 17, 21935-21941, 2015.

Surface plasmon enhanced energy transfer between gold nanorods and fluorophores: application to endosytosis study and RNA detection. Y Zhang W Guoke, J Yu, D Birch, Y Chen. Faraday Discussions, 178, 383-394 , 2015

Fluorescence. D J S Birch, Y Chen and O J Rolinski.“Biological and Medical Photonics, Spectroscopy and Microscopy.” Ed D L Andrews. Vol 4 “Photonics.” Wiley. Ch.1. 1-58, 2015.

Photoactivable heterocyclic cages in a comparative release study of butyric acid as a model drug. Piloto A M, Hungerford G, Sutter  J U, Soares  A M S, Costa SPG,  Goncalves M S T. J Photochem. Photobiol. A Chemistry, 299, 44-53, 2015.

Fast bi-exponential fluorescence lifetime imaging microscopy technique, D. D. Li, H. Yu and Y. Chen, Opt. Lett., 40, 336, 2015.

Electromagnetic enhancement of ordered silver nanorod arrays evaluated by discrete dipole approximation. G. Wei, J. Wang and Y. Chen*, Beilstein Journal of Nanotechnology, 6, 686 (2015)

Hardware-friendly bi-exponential fluorescence lifetime imaging algorithms and phasor approaches. D. Li and Y. Chen, Proc. SPIE 9536, Advanced Microscopy Techniques IV; and Neurophotonics II, 95360M (July 14, 2015); doi:10.1117/12.2183082.

A smart fluorescent ligand to optimize a ConA-based glucose sensing assay using fluorescence anisotropy. B M. Cummins, M Li, A K. Locke, David J S Birch, G Vigh, G L Coté. Biosensors and Bioelect.  53–60, 63, 2015.

Interaction of fluorophores with DNA and spermine using fluorescence spectroscopy. Gracie, W E Smith, P Yip, J U Sutter, D J S Birch, D Graham, K. Faulds. The Analyst. 3735 – 3743, 139, 2014.

Fluorescence kinetics of tryptophan in a heterogeneous environment
O J Rolinski and V Vyshemirsky. Methods Appl. Fluoresc. 2, 045002, 2014.

Inhibition of beta-amyloid aggregation by fluorescent dye labels. M Amaro, T Wellbrock, D J S Birch, O J Rolinski. Appl. Phys. Letts. 104, 063704, 2014.

Metal ion influence on eumelanin fluorescence and structure. J-U Sutter and D J S Birch. Methods Appl. Fluoresc. 2, 024005, 2014.

Dye-dope polystyrene-coated gold nanorods: towards wavelength tunable SPASER. P Gu, D J S Birch, Yu Chen. Methods Appl. Fluoresc. 2, 024004, 2014.

ConA-based glucose sensing using the long-lifetime azadioxatriangulenium fluorophore. M Cummins, J Simpson, Z Gryczynski, T J Sorensen, Bo W Laursen, D Graham, D J S Birch, G L Coté. SPIE Proc. SPIE Proc. 8951, 89510A, 2014.

Energy transfer between a biological labelling dye and gold nanorods. C Racknor, M R Singh, Y Zhang, D J S Birch and Y Chen. Methods Appl. Fluoresc. 2, 015002 (6 pages), 2014.

Nanometrology. D J S Birch and P Yip in “Fluorescence Spectroscopy and Microscopy: Methods and Protocols” edited by Yves Engelboroghs and Antonie Visser. Vol. 1076 Methods in Molecular Biology, Humana Press.  Ch.11, 279-302, 2014.

The effect of copper on eumelanin photophysics and morphology. D J S Birch and J U Sutter. Proc. of SPIE 8587, 858705 (6 pages), 2013.

Molecular rheometry: direct determination of viscosity in Lo and Ld lipid phases via fluorescence lifetime imaging. Y Wu, M Štefl, A Olzyńska, M Hof, G Yahioglu, P Yip, D R. Casey, O Ces, J Humpolíčkova and Marina K. Kuimova. Phys.Chem.Chem.Phys. 15, 14986-93, 2013.

Fluorescence intensity- and lifetime-based glucose sensing using glucose/galactose-binding protein. J C Pickup, F Khan, Z-L Zhi, J Coulter, D J S Birch.   J. Diabetes Sci. and Technol., 7(1), 62–71, 2013.

Initial stages of beta-amyloid Ab1-40 and Ab1-42 oligomerization observed using fluorescence decay and molecular dynamics analyses of tyrosine. M Amaro, K Kubiak-Ossowska, D J S Birch and O J Rolinski. Methods Appl. Fluoresc. 1, 015006 (13 pages), 2013.

Fluorescence Anisotropy of Protein – Gold Nanoclusters
C Li, J-U Sutter, D J S Birch and Y Chen
IEEE Nanotechnology 2012; ISBN 978-1-4673-2200-3.

Synthesis of vesicle cargo determines amplitude of Ca2+-sensitive exocytosis. J-U Sutter, J Denecke and G Thiel. Cell Calcium 52, 283-288, 2012.

Eumelanin fibrils. R. McQueenie, J Sutter, J Karolin and D J S Birch. J. Biomed. Opt. 17, 075001 (7 pages),  2012.

Creation and luminescence of size-selected gold nanorods. Y Chen, Y Zhang, D J S Birch and A S Barnard. Nanoscale. 4, 5017-22, 2012.

Fluorescence anisotropy metrology of electrostatically and covalently labelled silica nanoparticles. P Yip, J Karolin and D J S Birch. Meas. Sci. Technol. 23, 084003 (8 pages), 2012.

Growth and surface-enhanced Raman scattering of Ag nanoparticle assembly in agarose gel. M Keating, Y Chen, I A Larmour, K Faulds and D Graham. Meas. Sci. Technol. 23, 084006 (9 pages), 2012.

Reflectance and surface enhanced Raman scattering (SERS) of sculptured silver films deposited at various vapor incident angles. S Song, M Keating, Y Chen and F Placido. Meas. Sci. Technol. 23 ,084007 (6 pages), 2012.

Eumelanin Kinetics and Sheet Structure. J Sutter, T Bidláková, J Karolin and D J S Birch. Appl. Phys. Letts. 100, 113701 (4 pages), 2012.

CdSe/ZnS core/shell quantum dots as luminescence lifetime sensors for Cu2+ . J U Sutter, D J S Birch and O J Rolinski.  Meas. Sci. Technol. 23, 055103 (8 pages), 2012.

Effect of Size, Shape and Surface Modification on Cytotoxicity of Gold Nanoparticles to Human HEp-2 and Canine MDCK Cells. Y. Zhang, D. Xu, W. Li, J. Yu, Y. Chen, J. Nanomaterials, 375496 (7 pages), 2012.

Two-photon excited surface plasmon enhanced energy transfer between DAPI and gold nanoparticles : opportunities in intra-cellular imaging and sensing. Y Zhang, D J S Birch and Y Chen. Appl. Phys. Letts. 99, 103701-3, 2011.

Kinetic modelling of the shape-dependent evolution of faceted gold nanoparticles. A.S. Barnard and Y. Chen, J. Mater. Chem., 21, 12239-12245, 2011.

Fluorescence detections and directions. D J S Birch. Meas. Sci. Technol. 22, 052002 (8 pages), 2011.

Beta-Amyloid oligomerisation monitored by intrinsic fluorescence. M Amaro, D J S Birch and O J.Rolinski. Physical Chemistry Chemical Physics. 13, 6434-41, 2011.

The Effect of Intensity of Excitation on CdSe/ZnS Quantum Dots: Opportunities in Luminescence sensing. J U Sutter, D J S Birch and O J Rolinski.  Appl. Phys. Letts. 98,021108, 2011.

A Fluorescence Lifetime-Based Fibre-Optic Glucose Sensor Using Glucose/Galactose-Binding protein. T Saxl, F Khan, M Ferla, D J S Birch, and J Pickup. The Analyst. 136, 968-72, 2011.

Gold nanorods for fluorescence lifetime imaging in biology. Y Zhang, J Yu, D J S Birch and Y Chen. J Biomed. Opt. 15, 020504, 2010.

Early detection of amyloid aggregation using intrinsic fluorescence. O J Rolinski, M Amaro and D J S Birch. Biosensors and Bioelectronics. 25 (10),2249-52, 2010.

One- and two-photon time-resolved fluorescence study of neurotransmitter amino acid–5,6-benzocoumarin conjugates.  G Hungerford, L Ryderfors, M J G Fernandes, M Sameiro, T Gonçalves and S P G Costa. J. Photochem. Photobiol.  A-Chemistry, 215, 214-222, 2010.

Time-resolved FRET fluorescence spectroscopy of visible fluorescent protein pairs. A J W G  Visser, S P Laptenok, N V Visser, A van Hoek, D J S Birch, J-C Brochon, J W Borst. Eur. Biophys. J. 39, 241-53, 2010.

Interactions of the beta-blocker drug, propranolol, with detergents, beta-cyclodextrin and living cells studied using fluorescence spectroscopy and imaging. RH Bisby, SW Botchway, AG Crisostomo, J Karolin, AW Parker, L Schroder. Spectroscopy, 24, 137-142, 2010

Fluorescence biosensing in nanopores. Jan Karolin, Dalibor Panek, Alexander MacMillan, Olaf Rolinski, and David Birch. IEEE Proc. 978-1-4244-3296-7, 4154-7, 2009.

Protein fluorescence decay: a gamma function description of thermally induced inter conversion of amino acid rotamers. O J Rolinski, K Scobie and D J S Birch. Phys. Rev. E. 79, 050901, 2009.

Optical spectroscopic methods for probing the conformational stability of immobilized enzymes. A Ganesan, B D Moore, S M Kelly, N C Price, O J Rolinski, D J S Birch, I R Dunkin, P J Halling. ChemPhysChem 10, 1492-9, 2009.

Star-shaped oligofluorene nanostructured blend materials: controlled micro-patterning and physical characteristics. M Wu, E Gu, A Zarowna, A L Kanibolotsky, A J C Kuehne, A R Mackintosh, P R Edwards, O J Rolinski, I F Perepichka,  P J Skabara, R W Martin, R A Pethrick, D J S Birch and M D Dawson. Appl. Phys. A. 97, 19, 2009.

Nanoparticle metrology standards based on the time resolved fluorescence anisotropy of silica colloids. K Apperson, J Karolin, R W Martin and D J S Birch. Meas. Sci. Technol 20, 025310 (11 pages), 2009.

Improved biocompatibility of protein encapsulation in sol-gel materials. A M Macmillan, J Karolin, D Panek, C D McGuinness, J C Pickup, D Graham, W E Smith, and D J S Birch.J Sol-Gel Science & Technol. 49, 380-4, 2009.

Fluorescence lifetime spectroscopy and imaging of nano-engineered glucose sensor microcapsules based on glucose/galactose-binding protein. T Saxl, F Khan, D R Mathews, Zhi-ZL, O Rolnski, S Ameer-Beg and J Pickup. Biosensors and Bioelectronics 24, 3229-34, 2009.

Non-extensive kinetics of fluorescence resonance energy transfer. O J Rolinski and D J S Birch. J Chem Phys. 129, 144507-1-7, 2008.

The effect of pH on aqueous phenylalanine studied using a 265 nm pulsed light-emitting diode. A M Macmillan, C D McGuinness, K Sagoo, D McLoskey, J C Pickup and D J S Birch.Annals of the New York Academy of Sciences 1130, 300-4, 2008.

Towards Single Metal Ion Sensing by Förster Resonance Energy Transfer. Jens-Uwe Sutter, A M Macmillan, D J S Birch and O J Rolinski. Annals of the New York Academy of Sciences 1130, 62-7, 2008.

Human Serum Albumin-flavonoids interactions monitored by means of tryptophan kinetics. O J Rolinski, A Martin and D J S Birch. Annals of the New York Academy of Sciences 1130, 314-9, 2008.

Nanomedicine and its potential in diabetes research and practice. J C Pickup, Z-L Zhi, F Khan, T Saxl and D J S Birch. Diabetes/Metabolism Res. and Rev. 24, 604-610, 2008.

Fluorescence depolarization techniques in materials science. D J S Birch and J Karolin in Standardization and Quality Assurance in Fluorescence Measurements I: Techniques.  Vol. Ed. U Resch-Genger.Vol. 5, Springer Series on Fluorescence, 279–301, 2008.

HSA-quercetin interactions monitored by time-resolved fluorescence – evidence for enhanced discrete rotamer conformations. O J Rolinski, A Martin and D J S Birch. J. Biomed. Optics 12, 34013-7, 2007. (Also selected for publication in the Virtual Journal of Biological Physics Research).

Single molecule detection of allophycocyanin by surface enhanced resonance Raman scattering. C D McGuinness, A M Macmillan, J Karolin, W E Smith, D Graham, J C Pickup and D J Birch. Analyst 132, 633-4, 2007.

pH tracking of silica hydrogel nanoparticle growth. A Cleary, J Karolin and D J S Birch. Appl. Phys. Letts. 89, 113125-7, 2006. (Also selected for publication in the Virtual Journal of Nanoscale Science & Technology).

Excitation of fluorescence decay using a 265 nm pulsed light-emitting diode: evidence for aqueous phenylalanine rotamers. C D McGuinness, A M Macmillan, K Sagoo, D McLoskey and D J S Birch. Appl. Phys. Letts. 89, 063901-3, 2006. (Also selected for publication in the Virtual Journal of Biological Physics Research).

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